Key Takeaways
Your cellular energy is already declining.
NAD+ is a coenzyme found in every cell of your body. It sits at the center of cellular energy production, DNA repair, and the activation of proteins called sirtuins that regulate how your cells age.
The problem is that NAD+ declines with age — significantly and consistently. A landmark 2012 study from the University of New South Wales measured NAD+ levels across age groups in healthy adults and found that levels drop by approximately 50% between the ages of 20 and 50. The decline is not sudden. It starts in your late 20s and accelerates across each decade.
When NAD+ drops, cellular energy production becomes less efficient. DNA repair slows. The biological processes that keep your cells functioning optimally become progressively impaired. This is not a disease — it is a predictable consequence of aging that modern longevity research has been focused on addressing for over two decades.
Why three molecules and not one.
Most NAD+ supplements give you a single ingredient — usually nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) — and call it done. The research suggests this is incomplete.
NAD+ doesn't work in isolation. An enzyme called CD38 actively degrades NAD+ in your body, and its activity increases with age — which is part of why NAD+ declines in the first place. Supplementing NAD+ without addressing CD38 is like filling a bucket with a hole in it.
Quercetin is a natural CD38 inhibitor. Studies have shown that quercetin reduces CD38 activity, allowing NAD+ levels to be maintained more effectively. Without quercetin, a significant portion of supplemented NAD+ is degraded before it can be used.
Resveratrol activates a family of proteins called sirtuins — specifically SIRT1 — which are NAD+-dependent. Sirtuins regulate cellular stress responses, DNA repair, and metabolic function. Resveratrol without adequate NAD+ has nothing to activate. NAD+ without resveratrol leaves the sirtuin pathway underutilized. The two work together.
The three-molecule combination — NAD+ precursor, quercetin to preserve it, resveratrol to activate the pathways it powers — represents the most complete approach to NAD+ supplementation currently supported by the available research.
Why clinical doses matter.
The research on NAD+ precursors, quercetin, and resveratrol uses specific doses. Most studies examining NAD+ precursor efficacy use doses between 250mg and 1000mg daily. Quercetin studies examining CD38 inhibition use doses between 100mg and 500mg. Resveratrol studies examining sirtuin activation use doses between 100mg and 500mg.
Most supplements in this category either underdose — providing token amounts that fall below the ranges studied — or hide their doses inside proprietary blends that make it impossible to verify what you're actually getting.
Reloom uses 500mg NAD+, 250mg Quercetin, and 150mg Resveratrol. These doses sit within the ranges used in published research. Nothing is hidden. Every amount is stated on the label.